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KMID : 0617219980090010031
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Duksung Bulletin Phamaceutical Sciences
1998 Volume.9 No. 1 p.31 ~ p.50
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Study on the Stability Improvement of W/O/W Multiple Emulsion
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Abstract
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W/O/W multiple emulsion has been prepared by a two-step procedure using Sorbitan Emulsifiers. W/O/W Emulsion was evaluated by microscopy, viscosity and conduction resistivity test. The yield of W/O/W emulsion was measured by the dialysis method and the stability was estimated by measuring the viscosity and the extent of phase seperation as a function of time.
Aracel-83 produced more stable emulsion as compared with Aracel-80 or Aracel-85.
The ratio of Emulsifier Ⅰ to Emulsifier Ⅱ was the significant factor affecting the stability and the production yield of W/O/W Emulsion. The stability of W/O/W emulsion has been improved by adding Aluminum-stearate and Bees-wax as an oil phase thickner. Conduction Resistivity Test can be a useful method to optimize the second emulsification time.
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